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ARTÍCULOS ORIGINALES

Transforming growth factor  beta 1 modulates amyloid beta-induced glial activation through the smad3-dependent induction of MAPK phosphatase-1. Flores B and Von Bernhardi R. (2012). Journal of Alzheimer’s Disease.

 

Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?. Zolezzi JM, Silva-Alvarez C, Ordenes D, Carvajal FJ, Santos MJ and Inestrosa NC. (2013). Plos One.

 

Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics. Silva-Alvarez C, Arrázola MS, Godoy JA, Ordenes D and Inestrosa NC. (2013). Frontiers in Cellular Neuroscience.

 

SIRT1 Protects Dendrites, Mitochondria and Synapses from Aβ Oligomers in Hippocampal Neurons. Godoy JA, Allard C, Arrazola MS, Zolezzi JM, Inestrosa NC. (2013). Journal of Alzheimers Disease and Parkinsonism.

 

Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons. Muñoz, F. J., Godoy, J. A., Cerpa, W., Poblete, I. M., Huidobro-Toro, J. P., & Inestrosa, N. C. (2014). Biochemical and Biophysical Research Communications.

 

Wnt-5a Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons. Godoy JA, Arrázola MS, Ordenes D, Silva-Alvarez C, Braidy N, Inestrosa NC. (2014). Journal of Biological Chemistry.

 

Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: Auto regulation of GSK-3β in vivo. Tapia-Rojas C, Schüller A, Lindsay CB, Ureta RC, Mejías-Reyes C, Hancke J, Melo F, Inestrosa NC. (2014). Biochemical Journal.

 

Age progression of neuropathological markers in the brain of the chilean rodent Octodon degus, a natural mod- el of Alzheimer’s disease. Inestrosa NC, Ríos JA, Cisternas P, Tapia-Rojas C, Rivera DS, Braidy N, Zolezzi JM, Godoy JA, Carvajal FJ, Ardiles AO, Bozinovic F, Palacios AG, Sachdev PS. (2014). Brain Pathology.

 

Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice. Serrano FG, Tapia-Rojas C, Carvajal FJ, Hancke J, Cerpa W, Inestrosa NC. (2014). Molecular Neurodegeneration.

 

WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers. Vargas JY, Ahumada J, Arrázola MS, Fuenzalida M, Inestrosa NC. (2015). Experimental Neurology.

 

p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing. Posa- da-Duque RA, López-Tobón A, Piedrahita D, González-Billault C, Cardona-Gomez GP. (2015). Journal of Neurochemistry.

 

Transgenic overexpression of Niemann-Pick C2 protein promotes cholesterol gallstone formation in mice. Acuña M, González-Hódar L, Amigo L, Castro J, Morales MG, Cancino GI, Groen AK, Young J, Miquel JF, Zanlungo S. (2015). Journal of Hepatology.

 

The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer’s disease. Cisternas P, Lindsay CB, Salazar P, Silva-Alvarez C, Retamales RM, Serrano FG, Vio CP, Inestrosa NC. (2015). Biochim Biophys Acta.

 

Rhein-huprine derivatives reduce cognitive impairment, synaptic failure and amyloid pathology in AβPPswe/ PS-1 mice of di erent ages. Serrano FG, Tapia-Rojas C, Carvajal FJ, Cisternas P, Viayna E, Irene S, Muñoz-Torre- ro D, Inestrosa NC. (2015). Curr Alzheimer Res.

 

CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1. Posada-Duque RA, Pala- cio-Castañeda V, Cardona-Gómez GP. (2015). Molecular Cellular Neuroscience.

 

Regulation of memory formation by the transcription factor XBP1. Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles A, Wirth C, Valdés P, Thielen P, Schneider BL, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH and Hetz C. Cell Report, 2015.

 

Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons. Codocedo JF, Inestrosa NC. (2016). Biol Res.

 

Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation. Ramírez VT, Ramos-Fernández E, Henríquez JP, Lorenzo A, Inestrosa NC. (2016). J Biol Chem.

 

Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons. Cisternas P, Salazar P, Silva-Álvarez C, Barros LF, Inestrosa NC. (2016). Neural Plast.

 

Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis. Cisternas P, Salazar P, Silva-Álvarez C, Barros LF, Inestrosa NC. (2016). J Biol Chem.

 

Quercetin Exerts Di erential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria. Godoy JA, Lindsay CB, Quintanilla RA, Carvajal FJ, Cerpa W, Inestrosa NC. (2016). Mol Neurobiol.

 

Silencing strategies for therapy of SOD1-mediated ALS. van Zundert B, Brown RH Jr. (2017). Neurosci Lett.

 

High glucocorticoid levels during gestation activate the in ammasome in hippocampal oligodendrocytes of the offspring. Maturana CJ, Aguirre A, Sáez JC. (2016). Dev Neurobiol.

 

Structural and functional analysis of the ASM p.Ala359Asp mutant that causes acid sphingomyelinase deficiency. Acuña M, Castro-Fernández V, Latorre M, Castro J, Schuchman EH, Guixé V, González M, Zanlungo S. (2016). Biochem Biophys Res Commun.

 

CyDiv, a Conserved and Novel Filamentous Cyanobacterial Cell Division Protein Involved in Septum Localization. Mandakovic D, Trigo C, Andrade D, Riquelme B, Gómez-Lillo G, Soto-Liebe K, Díez B, Vásquez M. (2016). Front Microbiol.

 

 Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons. Ramos-Fernández E, Tajes M, Ill-Raga G, Vargas L, Busquets-García A, Bosch-Morató M, Guiver- nau B, Valls-Comamala V, Gomis M, Grau C, Fandos C, Rosen MD, Rabinowitz MH, Inestrosa N, Maldonado R, Altafaj X, Ozaita A, Alvarez A, Vicente R, Valverde MA, Muñoz FJ. (2016). Oncotarget.

 

Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-β (Aβ)42 peptides. Tapia-Rojas C, Burgos PV, Inestrosa NC. (2016). J Neurochem.

 

Identification of novel cellular clusters define a specialized area in the cerebellar periventricular zone. María Alejandra González-González, Gabriela B. Gómez-González, Marymar Becerra-González & Ataúlfo Martínez-Torres. Scientific Report, Nature (2017).

 

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